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Clesrovimab - Merck Sharp & Dohme

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Drug Profile

Clesrovimab - Merck Sharp & Dohme

Alternative Names: Anti RSV F antibody - Merck Sharp & Dohme; clesrovimab-cfor - Merck Sharp & Dohme; ENFLONSIA; Enflonsia; MK-1654

Latest Information Update: 23 Feb 2026

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antivirals; Monoclonal antibodies
  • Mechanism of Action Viral fusion protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Respiratory syncytial virus infections

Most Recent Events

  • 19 Feb 2026 Updated efficacy, pharmacokinetics and adverse events data from the phase III SMART trial in Respiratory syncytial virus infections released by Merck Sharp & Dohme
  • 05 Feb 2026 Registered for Respiratory syncytial virus infections (In neonates, In infants, Prevention) in Canada (IM)
  • 05 Feb 2026 Adverse events data from a phase IIb/III CLEVER trial in Respiratory syncytial virus infections released by Merck

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