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Maplirpacept - Trillium Therapeutics

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Drug Profile

Maplirpacept - Trillium Therapeutics

Alternative Names: CD47Fc; PF-07901801; SIRPa-IgG4-Fc; TTI-622

Latest Information Update: 28 Nov 2024

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At a glance

  • Originator The Hospital for Sick Children; University Health Network
  • Developer Incyte Corporation; MorphoSys; Pfizer
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; Phagocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haematological malignancies
  • Phase I/II Acute myeloid leukaemia; Diffuse large B cell lymphoma; Multiple myeloma; Ovarian cancer
  • Phase I Lymphoma; Non-Hodgkin's lymphoma
  • Preclinical Solid tumours

Most Recent Events

  • 28 Nov 2024 No recent reports of development identified for phase-I development in Multiple-myeloma(Combination therapy, In the elderly, Second-line therapy or greater, In adults) in USA (IV, Infusion)
  • 06 Nov 2024 Pfizer completes phase I trial in Multiple myeloma and Non-Hodgkin Lymphoma (Late-stage disease, Monotherapy, Second-line therapy or greater) in China (IV) (NCT05896774)
  • 02 Oct 2024 Pfizer completes a phase I trial in Lymphoma and Multiple myeloma (Monotherapy, Second-line therapy or greater) in Japan (IV) (NCT05567887)

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