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Maplirpacept - Trillium Therapeutics

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Drug Profile

Maplirpacept - Trillium Therapeutics

Alternative Names: CD47Fc; PF-07901801; SIRPa-IgG4-Fc; TTI-622

Latest Information Update: 17 Jul 2026

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At a glance

  • Originator The Hospital for Sick Children; University Health Network
  • Developer Incyte Corporation; MorphoSys; Pfizer
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; Phagocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Diffuse large B cell lymphoma; Haematological malignancies; Lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Ovarian cancer; Solid tumours

Most Recent Events

  • 01 Jul 2026 Memorial Sloan Kettering Cancer Center and Trillium therapeutics completes a phase I trial in Multiple myeloma (Second-line therapy or greater, Combination therapy) in USA (IV) (NCT05139225)
  • 11 May 2026 Discontinued - Phase-I for Lymphoma (Monotherapy, Late-stage disease, Second-line therapy or greater) in USA (IV)
  • 11 May 2026 Discontinued - Phase-I for Lymphoma (Monotherapy, Second-line therapy or greater) in Japan (IV)

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