Vudalimab - Xencor
Alternative Names: PD-1 x CTLA-4 - Xencor; XmAb 717; XmAb-20717Latest Information Update: 04 Oct 2024
At a glance
- Originator Xencor
- Class Antineoplastics; Bispecific antibodies; Immunotherapies
- Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase II Biliary cancer; Gynaecological cancer; Prostate cancer; Urogenital cancer
- Phase I/II Non-small cell lung cancer
Most Recent Events
- 19 Sep 2024 Emory University in collaboration with Xencor suspends a phase I trial in Prostate cancer (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in USA (IV) to review the safety data (NCT05733351)
- 27 Feb 2024 Efficacy and adverse events data from a phase II trial in Prostate cancer released by Xencor
- 13 Feb 2024 M.D. Anderson Cancer Center in collaboration with Xencor withdrew phase II RX-CROME trial prior to enrolment in Colorectal cancer (IV) (NCT05900648)