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Vudalimab - Xencor

Drug Profile

Vudalimab - Xencor

Alternative Names: PD-1 x CTLA-4 - Xencor; XmAb 717; XmAb-20717

Latest Information Update: 04 Mar 2024

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At a glance

  • Originator Xencor
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Biliary cancer; Gynaecological cancer; Prostate cancer; Urogenital cancer
  • Phase I/II Non-small cell lung cancer

Most Recent Events

  • 27 Feb 2024 Efficacy and adverse events data from a phase II trial in Prostate cancer released by Xencor
  • 13 Feb 2024 M.D. Anderson Cancer Center in collaboration with Xencor withdrew phase II RX-CROME trial prior to enrolment in Colorectal cancer (IV) (NCT05900648)
  • 27 Dec 2023 Phase-I/II clinical trials in Non-small cell lung cancer (First-line therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Combination therapy) in USA (IV) (Xencor pipeline; December 2023) (NCT06173505)
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