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Botensilimab - Agenus

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Drug Profile

Botensilimab - Agenus

Alternative Names: AGEN-1181; Anti-CTLA-4 Monoclonal Antibody AGEN1181; BOT - Agenus; Fc-enhanced CTLA-4 antibody

Latest Information Update: 23 Feb 2026

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At a glance

  • Originator Agenus
  • Developer Agenus; Immune Oncology Research Institute
  • Class Antibodies; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Solid tumours
  • Phase II Adenocarcinoma; Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Rectal cancer; Renal cell carcinoma
  • Clinical Phase Unknown Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Soft tissue sarcoma

Most Recent Events

  • 19 Feb 2026 Updated efficacy and biomarkers data from a phase Ib trial in Solid tumours released by Agenus
  • 28 Jan 2026 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in United Kingdom (IV, Infusion)
  • 28 Jan 2026 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in United Kingdom (IV, Infusion)

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