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Botensilimab - Agenus

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Drug Profile

Botensilimab - Agenus

Alternative Names: AGEN-1181; Anti-CTLA-4 Monoclonal Antibody AGEN1181; BOT - Agenus; Fc-enhanced CTLA-4 antibody

Latest Information Update: 01 Sep 2026

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At a glance

  • Originator Agenus
  • Developer Agenus; Immune Oncology Research Institute; Scripps Health
  • Class Antibodies; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Adenocarcinoma
  • Phase II/III Solid tumours
  • Phase II Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Rectal cancer; Renal cell carcinoma
  • Phase I Cervical cancer
  • Clinical Phase Unknown Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Soft tissue sarcoma

Most Recent Events

  • 28 Aug 2026 Efficacy, adverse events and pharmacodynamics data from the phase Ib trial in Colorectal cancer released by Agenus
  • 26 Aug 2026 Efficacy and adverse events data from the phase-II NEST-1 trial in Colorectal cancer released by Agenus
  • 18 Aug 2026 Phase-II clinical trials in Rectal cancer (Neoadjuvant therapy, Combination therapy, Early-stage disease) in USA (IV) (NCT07735624)

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