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MK 4830

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Drug Profile

MK 4830

Alternative Names: MK-4830

Latest Information Update: 17 Jun 2024

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At a glance

  • Originator Agenus
  • Developer Merck Sharp & Dohme; Presage Biosciences
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; LILRB2 protein inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ovarian cancer
  • Phase 0 Head and neck cancer; Soft tissue sarcoma
  • Discontinued Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours

Most Recent Events

  • 17 Jun 2024 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable, Recurrent, Second-line therapy or greater) in Australia, China, France, Greece, Japan, South Korea, Poland, Poland, South Africa, Spain (IV)
  • 17 Jun 2024 Discontinued - Phase-I for Solid tumours (Monotherapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable, Recurrent, Second-line therapy or greater) in Australia, China, France, Greece, Japan, South Korea, Poland, Poland, South Africa, Spain (IV)
  • 05 Apr 2024 Efficacy and adverse events data from the phase Ib/II KEYNOTE-B98 trial in Small cell lung cancer presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)

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