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Rencofilstat - Hepion Pharmaceuticals

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Drug Profile

Rencofilstat - Hepion Pharmaceuticals

Alternative Names: CRV-431; Cyclosporine A analogue- Hepion Pharmaceuticals

Latest Information Update: 15 Nov 2023

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At a glance

  • Originator Isotechnika
  • Developer ContraVir Pharmaceuticals; Hepion Pharmaceuticals; HepQuant
  • Class Anti-inflammatories; Antifibrotics; Antineoplastics; Antiretrovirals; Antivirals; Cardiovascular therapies; Ciclosporins; Hepatoprotectants; Small molecules
  • Mechanism of Action Cyclophilin inhibitors; Sodium-bile acid cotransporter modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Liver cancer; Non-alcoholic steatohepatitis
  • Phase I/II Hepatitis B
  • Preclinical Cardiomyopathies; COVID 2019 infections; Hepatic fibrosis; Idiopathic pulmonary fibrosis; Liver disorders; Multiple myeloma; Non-alcoholic fatty liver disease; Prostate cancer; Renal fibrosis; SARS-CoV-2 acute respiratory disease
  • No development reported Hepatitis D
  • Discontinued Coronavirus infections; Hepatitis C; HIV-1 infections; Human papillomavirus infections

Most Recent Events

  • 13 Nov 2023 Efficacy data from the phase II ALTITUDE-NASH trial in Non-alcoholic steatohepatitis released by Hepion Pharmaceuticals
  • 25 Oct 2023 Pharmacodynamics data from a preclinical trial in Cancer released by Hepion Pharmaceuticals
  • 21 Sep 2023 Pharmacodynamics data from a preclinical trial in Cancer released by Hepion Pharmaceuticals
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