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Nivolumab/relatlimab - Bristol-Myers Squibb

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Drug Profile

Nivolumab/relatlimab - Bristol-Myers Squibb

Alternative Names: BMS-936558/BMS-986016; BMS-986213; Nivolumab and relatlimab-rmbw - Bristol-Myers Squibb; Nivolumab/relatlimab-rmbw - Bristol Myers Squibb; Opdualag; Relatlimab-rmbw/nivolumab - Bristol Myers Squibb; Relatlimab/nivolumab - Bristol Myers Squibb

Latest Information Update: 28 Jun 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma
  • Phase III Colorectal cancer; Gastric cancer; Non-small cell lung cancer
  • Phase II Squamous cell cancer
  • Phase I/II Solid tumours
  • No development reported Haematological malignancies

Most Recent Events

  • 28 Jun 2025 No recent reports of development identified for phase-I development in Haematological-malignancies in USA (IV)
  • 02 Apr 2025 Bristol-Myers Squibb terminates a Phase-III clinical trials in Malignant melanoma (In adolescents, In children, In the elderly, Late-stage disease, Adjuvant therapy, In adults) in Greece, Romania (IV) due to inability to meet protocol objectives (NCT05002569) (EudraCT2021-001641-13)
  • 07 Oct 2024 Phase-III clinical trials in Non-small cell lung cancer (Recurrent, Late-stage disease, Metastatic disease, First-line therapy, Combination therapy) in USA (unspecified route) (NCT06561386)

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