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Orforglipron - Eli Lilly and Company

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Drug Profile

Orforglipron - Eli Lilly and Company

Alternative Names: GLP-1 receptor NPA - Eli Lilly and Company; Glucagon like peptide 1 receptor NPA - Eli Lilly and Company; LY-3502970; OWL 833

Latest Information Update: 26 Jun 2025

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At a glance

  • Originator Chugai Pharmaceutical
  • Developer Eli Lilly and Company
  • Class Antihyperglycaemics; Antihypertensives; Fluorinated hydrocarbons; Imidazoles; Indazoles; Indoles; Ketones; Obesity therapies; Oxadiazoles; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hypertension; Obesity; Sleep apnoea syndrome; Type 2 diabetes mellitus

Most Recent Events

  • 24 Jun 2025 Efficacy data from a phase III ACHIEVE-1 trial in Type II diabetes mellitus released by Eli Lilly and Company
  • 21 Jun 2025 Eli Lilly and Company plans to submit regulatory application for Obesity to global regulatory agencies by the end of 2025
  • 21 Jun 2025 Eli Lilly and Company plans to submit regulatory application for Type 2 diabetes mellitus to global regulatory agencies in 2026

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