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CTX 471

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Drug Profile

CTX 471

Alternative Names: CTX-471

Latest Information Update: 12 Mar 2026

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At a glance

  • Originator Adimab
  • Developer Compass Therapeutics; Merck & Co
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD137 antigen agonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 05 Mar 2026 Compass Therapeutics plans a phase II trial in Solid tumours (IV) mid-2026
  • 06 Feb 2026 Washington University School of Medicine plans a phase I/II trial for Glioblastoma (Monotherapy, Combination therapy, Second-line therapy or greater, Late stage disease) in USA in March 2026 (IV)(NCT07392957)
  • 21 May 2025 Compass Therapeutics completes a phase-I trial in Solid tumours (Monotherapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV, Infusion) (NCT03881488)

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