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Sotorasib - Amgen

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Drug Profile

Sotorasib - Amgen

Alternative Names: AMG-510; LUMAKRAS; LUMYKRAS

Latest Information Update: 19 Sep 2025

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At a glance

  • Originator Amgen; Carmot Therapeutics
  • Developer Amgen; BeOne Medicines; REVOLUTION Medicines; Verastem Oncology
  • Class Antineoplastics; Piperazines; Pyridines; Pyridones; Pyrimidines; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Colorectal cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Non-small cell lung cancer
  • Phase III Solid tumours
  • Phase I/II Brain metastases; Pancreatic cancer

Most Recent Events

  • 15 Sep 2025 Amgen plans a phase-II trial for Solid tumours (Monotherapy, Combination therapy, Late-stage disease, Second-line therapy or greater) in October 2025 (PO), (NCT07172919)
  • 25 Jul 2025 Launched for Colorectal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 30 May 2025 Pharmacodynamics data from a phase III trial in Colorectal cancer presented at 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)

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