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AUTO 4

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Drug Profile

AUTO 4

Alternative Names: Anti-TRBC1 CAR T-cells - Autolus; AUTO-4; RQR8/aTRBC1 CAR T cells - Autolus

Latest Information Update: 27 May 2025

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At a glance

  • Originator University College London
  • Developer Autolus
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II T-cell lymphoma

Most Recent Events

  • 12 Dec 2024 Autolus completes a Phase-I/II trial in T-cell lymphoma (Second-line therapy or greater) in Spain and United Kingdom (IV) (NCT03590574)
  • 28 Apr 2024 No recent reports of development identified for phase-I development in T-cell-lymphoma(Second-line therapy or greater) in China (IV)
  • 12 Dec 2022 Efficacy and safety data from a phase-I/II trial in T-cell lymphoma were released by Autolus Therapeutics

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