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Ponsegromab - Pfizer

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Drug Profile

Ponsegromab - Pfizer

Alternative Names: PF 06946860

Latest Information Update: 31 Oct 2025

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At a glance

  • Originator Pfizer
  • Class Appetite stimulants; Heart failure therapies; Monoclonal antibodies
  • Mechanism of Action Growth differentiation factor 15 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Adenocarcinoma; Cachexia
  • Discontinued Heart failure

Most Recent Events

  • 03 Oct 2025 Phase-II/III clinical trials in Adenocarcinoma (Metastatic disease) in Puerto Rico, Japan, Israel, Australia, USA (SC) (NCT06989437)
  • 03 Oct 2025 Phase-II/III clinical trials in Cachexia in Israel, Puerto Rico, Japan, Australia, USA (SC) (NCT06989437)
  • 30 May 2025 Efficacy data from a phase II trial in Cachexia presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)

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