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Olpasiran - Amgen

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Drug Profile

Olpasiran - Amgen

Alternative Names: AMG-890; ARC LPA; ARO LPA; RNAi ARC-LPA

Latest Information Update: 08 May 2026

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At a glance

  • Originator Arrowhead Pharmaceuticals
  • Developer Amgen
  • Class Cardiovascular therapies; Small interfering RNA
  • Mechanism of Action Lipoprotein A expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cardiovascular disorders

Most Recent Events

  • 23 Mar 2026 Amgen initiates the phase III OCEAN(a)-CCTA trial for Cardiovascular disease in the US, Australia, Canada, China, Denmark, France, Germany, Italy, Japan, the Netherlands and Spain (NCT07293260)
  • 08 Nov 2025 Efficacy data from a phase-II OCEAN(a)-DOSE trial in Cardiovascular presented at the American Heart Association Scientific Sessions 2025 (AHA-2025)
  • 22 Aug 2025 Amgen initiates the phase III OCEAN(a)-PreEvent trial for Cardiovascular disorders in USA, Australia, Canada (SC, Injection) (NCT07136012)

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