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Tuparstobart - Agenus

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Drug Profile

Tuparstobart - Agenus

Alternative Names: Anti-LAG-3 Monoclonal Antibody INCAGN02385; INCAGN-02385; INCAGN-2385

Latest Information Update: 20 Jan 2025

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At a glance

  • Originator Agenus
  • Developer Agenus; Incyte Corporation; University of Washington
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer; Squamous cell cancer
  • Phase I/II Malignant melanoma; Solid tumours
  • Phase I Merkel cell carcinoma
  • No development reported Diffuse large B cell lymphoma

Most Recent Events

  • 08 Sep 2024 Pharmacokinetics and pharmacodynamics data from a phase I trial in Solid tumours presented at the 2024 American College of Clinical Pharmacology Annual Meeting (ACCP-2024)
  • 19 Oct 2023 Phase-I clinical trials in Merkel cell carcinoma (Late-stage disease, Second-line therapy or greater, Combination therapy, Refractory metastatic disease) in USA (IV)
  • 02 Jun 2023 Efficacy and adverse events data from a phase I/II trial in Solid tumours and Malignant melanoma presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)

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