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SAGE 324

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Drug Profile

SAGE 324

Alternative Names: BIIB-124; SAGE-324

Latest Information Update: 01 Aug 2025

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At a glance

  • Originator SAGE Therapeutics
  • Class Antiepileptic drugs; Antiparkinsonians; Small molecules
  • Mechanism of Action GABA A receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Epilepsy
  • No development reported Parkinson's disease
  • Discontinued Essential tremor

Most Recent Events

  • 31 Jul 2025 SAGE Therapeutics has been acquired by Supernus Pharmaceuticals
  • 20 Feb 2025 SAGE 324 is still in phase I trials for Epilepsy in the US (Sage Therapeutics pipeline, February 2025)
  • 11 Feb 2025 Biogen and Sage Therapeutics terminates the collaboration to develop and commercialize SAGE 324 for Essential tremors, Epilepsy and Parkinson's disease (SAGE Therapeutics pipeline, February 2025)

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