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Tadnersen - Ionis Pharmaceuticals

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Drug Profile

Tadnersen - Ionis Pharmaceuticals

Alternative Names: BIIB-078; BIIB-078 free acid; IONIS-C9Rx; Tadnersen sodium - Ionis Pharmaceuticals

Latest Information Update: 31 Mar 2022

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Biogen; Ionis Pharmaceuticals
  • Class Antisense oligonucleotides; Thionucleotides
  • Mechanism of Action C9orf72 protein inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Amyotrophic lateral sclerosis

Most Recent Events

  • 28 Mar 2022 Discontinued - Phase-I for Amyotrophic lateral sclerosis (Adjuvant therapy) in Ireland, United Kingdom, Switzerland, Switzerland, Netherlands, Canada, USA (Intrathecal) due to unmet secondary efficacy endpoints and no clinical benefits (NCT04288856)
  • 28 Mar 2022 Efficacy and adverse events data from a phase I trial in Amyotrophic lateral sclerosis released by Biogen and Ionis Pharmaceuticals
  • 28 Mar 2022 Biogen discontinues a phase I trial in Amyotrophic lateral sclerosis (Adjuvant therapy) in USA (Intrathecal) due to unmet secondary efficacy endpoints and no clinical benefits (NCT04288856)

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