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SP 16

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Drug Profile

SP 16

Alternative Names: Serpin Peptide 16; SP-16

Latest Information Update: 20 Aug 2026

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At a glance

  • Originator Serpin Pharma
  • Developer Serpin Pharma; Virginia Commonwealth University
  • Class Analgesics; Anti-inflammatories; Anti-ischaemics; Antihyperglycaemics; Cardiovascular therapies; Oligopeptides; Peptides; Serpins; Skin disorder therapies
  • Mechanism of Action Low density lipoprotein receptor-related protein-1 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Inflammation; Myocardial infarction; SARS-CoV-2 acute respiratory disease
  • Preclinical Acute kidney injury; Atopic dermatitis; Chronic inflammatory demyelinating polyradiculoneuropathy; Eosinophilic oesophagitis; Neuropathic pain
  • Research Alopecia areata; Pemphigus vulgaris
  • No development reported Diabetes mellitus; Myocardial reperfusion injury

Most Recent Events

  • 13 Aug 2026 Serpin Pharma plans a phase Ib trial for Neuropathic pain and Peripheral-neuropathies (IV) in the second half of 2026
  • 15 Apr 2026 The US FDA clears IND application of SP 16 for Chemotherapy induced neuropathy
  • 02 Mar 2026 Serpin Pharma plans a phase II EASE AKI trial for Acute kidney injury (Prevention) in Germany (SC, Injection) (CTIS2025-522491-89-00)

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