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COM 701

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Drug Profile

COM 701

Alternative Names: anti-PVRIG antibody; CGEN-15029; COM-701; COM701/PVRIG

Latest Information Update: 20 Nov 2025

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At a glance

  • Originator Compugen
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD112 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Ovarian cancer; Solid tumours

Most Recent Events

  • 21 Jul 2025 Phase-I/II clinical trials in Ovarian cancer (Second-line therapy or greater) in Israel, France (IV) (NCT06888921)
  • 24 Apr 2025 Phase-I/II clinical trials in Ovarian cancer (Second-line therapy or greater) in USA (IV) (NCT06888921)
  • 25 Mar 2025 Compugen plans a phase I/II trial for Ovarian cancer (maintenance therapy, Second-line or greater therapy) in march 2025 (IV) (NCT06888921)

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