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COM 701

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Drug Profile

COM 701

Alternative Names: anti-PVRIG antibody; CGEN-15029; COM-701; COM701/PVRIG

Latest Information Update: 19 Nov 2024

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At a glance

  • Originator Compugen
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD112 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 19 Nov 2024 Compugen plans to initiate an adaptive platform trial in patients with Ovarian cancer (Second-line therapy or greater) to evaluate single agent COM 701 maintenance treatment or placebo in the second quarter of 2025
  • 05 Nov 2024 Efficacy and adverse events data from phase-I trial in Solid tumours released by Compugen
  • 31 May 2024 adverse events and efficacy data from phase I trial in Solid tumours presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)

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