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LMP 744

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Drug Profile

LMP 744

Alternative Names: LMP744; MJ-III-65; NSC 706744

Latest Information Update: 25 Jul 2025

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At a glance

  • Originator Linus Oncology; National Cancer Institute (USA); Purdue University
  • Developer Gibson Oncology; National Cancer Institute (USA)
  • Class Antineoplastics; Dioxoles; Indenes; Isoquinolines; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Lymphoma; Solid tumours
  • Preclinical Breast cancer; Glioblastoma

Most Recent Events

  • 25 Jul 2025 LMP 744 is still in phase I trials for Lymphoma and Solid tumours (Second-line therapy or greater) in USA (NCT03030417)
  • 24 Sep 2024 LMP 744 receives Orphan Drug status for Glioma in USA
  • 12 Oct 2023 The National Cancer Institute (NCI) completed a phase I trial in Lymphoma (Second-line therapy or greater) and Solid tumours (Second-line therapy or greater) in USA (IV) (NCT03030417)

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