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Azercabtagene zapreleucel - Precision BioSciences

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Drug Profile

Azercabtagene zapreleucel - Precision BioSciences

Alternative Names: Allogeneic-anti-CD19-CAR-T-cells-Precision-BioSciences/Servier; anti-CD19 CAR T Cells - Precision BioSciences/Servier; anti-CD19 chimeric antigen receptor T-cell therapy - Precision BioSciences/Servier; Azer-Cel; PBCAR-0191

Latest Information Update: 29 Jul 2025

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At a glance

  • Originator Baxalta; Precision Biosciences
  • Developer Imugene; Precision Biosciences; TG Therapeutics
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Phase I Diffuse large B cell lymphoma; Multiple sclerosis; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 29 Jul 2025 Azercabtagene zapreleucel is still in phase I trials for Precursor-B-cell-lymphoblastic-leukaemia-lymphoma and Non-Hodgkin's-lymphoma (Second-line therapy or greater) in USA (IV, Infusion) (NCT03666000)
  • 28 Jul 2025 No recent reports of development identified for phase-I development in Non-Hodgkin's-lymphoma(Second-line therapy or greater) in USA (IV, Infusion)
  • 28 Jul 2025 No recent reports of development identified for phase-I development in Precursor-B-cell-lymphoblastic-leukaemia-lymphoma(Second-line therapy or greater) in USA (IV, Infusion)

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