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Enpatoran - Merck KGaA

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Drug Profile

Enpatoran - Merck KGaA

Alternative Names: M-5049

Latest Information Update: 19 Jun 2025

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At a glance

  • Originator EMD Serono Research & Development Institute; Merck KGaA
  • Class Amines; Anti-inflammatories; Antivirals; Nitriles; Piperidines; Quinolines; Skin disorder therapies; Small molecules
  • Mechanism of Action Toll-like receptor 7 antagonists; Toll-like receptor 8 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II COVID-19 pneumonia; Cutaneous lupus erythematosus; Dermatomyositis; Polymyositis; Systemic lupus erythematosus
  • No development reported Immunological disorders; Unspecified

Most Recent Events

  • 12 Jun 2025 Efficacy data from a phase II WILLOW trial in Systemic lupus erythematous released by Merck
  • 28 May 2025 No recent reports of development identified for phase-I development in Systemic-lupus-erythematosus in Ukraine (PO)
  • 28 May 2025 No recent reports of development identified for phase-I development in Systemic-lupus-erythematosus(In the elderly, In adults) in Macedonia (PO)

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