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Aficamten - Cytokinetics

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Drug Profile

Aficamten - Cytokinetics

Alternative Names: CK 3773274; CK-274

Latest Information Update: 25 May 2025

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At a glance

  • Originator Cytokinetics
  • Developer Corxel Pharmaceuticals; Cytokinetics
  • Class Amides; Cardiovascular therapies; Heart failure therapies; Indenes; Oxadiazoles; Pyrazoles; Small molecules
  • Mechanism of Action Cardiac myosin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypertrophic cardiomyopathy
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Hypertrophic cardiomyopathy

Most Recent Events

  • 13 May 2025 Adverse events and efficacy data from phase III MAPLE-HCM trial in Hypertrophic cardiomyopathy released by Cytokinetics
  • 01 May 2025 FDA assigns PDUFA action date of (26/12/2025) for Aficamten for hypertrophic cardiomyopathy
  • 01 May 2025 US FDA requests Risk Evaluation and Mitigation Strategy (REMS) of aficamten for Hypertrophic cardiomyopathy

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