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T cell receptor gene therapy - Precigen Inc/Alaunos Therapeutics

Drug Profile

T cell receptor gene therapy - Precigen Inc/Alaunos Therapeutics

Alternative Names: Sleeping Beauty TCR-T; TCR T-cell therapy - Precigen Inc/Alaunos Therapeutics

Latest Information Update: 22 Mar 2024

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At a glance

  • Originator Intrexon Corporation
  • Developer National Cancer Institute (USA); Precigen Inc; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; KRAS protein expression modulators; P53 gene modulators; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Solid tumours

Most Recent Events

  • 08 Mar 2024 National Cancer Institute withdraws phase II trial in Solid tumours (Metastatic disease, Second-line therapy or greater) in USA, due to difficulty with availability of GLP-grade reagents for manufacturing.(NCT04102436)
  • 02 Jun 2023 Updated adverse events and efficacy data from a phase I/II trial in Solid tumors presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 03 Apr 2023 Precigen regains its exclusive rights from Alaunos Therapeutics

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