T cell receptor gene therapy - Precigen Inc/Alaunos Therapeutics
Alternative Names: Sleeping Beauty TCR-T; TCR T-cell therapy - Precigen Inc/Alaunos TherapeuticsLatest Information Update: 22 Mar 2024
At a glance
- Originator Intrexon Corporation
- Developer National Cancer Institute (USA); Precigen Inc; University of Texas M. D. Anderson Cancer Center
- Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
- Mechanism of Action Immunologic cytotoxicity; KRAS protein expression modulators; P53 gene modulators; T lymphocyte replacements
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Phase II Solid tumours
Most Recent Events
- 08 Mar 2024 National Cancer Institute withdraws phase II trial in Solid tumours (Metastatic disease, Second-line therapy or greater) in USA, due to difficulty with availability of GLP-grade reagents for manufacturing.(NCT04102436)
- 02 Jun 2023 Updated adverse events and efficacy data from a phase I/II trial in Solid tumors presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
- 03 Apr 2023 Precigen regains its exclusive rights from Alaunos Therapeutics