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DNX 2440

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Drug Profile

DNX 2440

Alternative Names: Delta-24-RGDOX; DNX-2440

Latest Information Update: 28 Apr 2025

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At a glance

  • Originator University of Texas M. D. Anderson Cancer Center
  • Developer DNAtrix; University of Navarra
  • Class Antineoplastics; Gene therapies; Immunotherapies; Oncolytic viruses
  • Mechanism of Action Cell death stimulants; Immunologic cytotoxicity; OX40 receptor agonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • No development reported Glioblastoma; Liver metastases

Most Recent Events

  • 28 Apr 2025 No recent reports of development identified for phase-I development in Glioblastoma(Recurrent) in Spain (Intratumoural, Injection)
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Liver metastases in USA (Intratumoural, Injection)
  • 09 Apr 2024 DNAtrix terminates a Phase-I clinical trials in Liver metastases in USA (Intratumoural) due to management decision (NCT04714983)

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