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MB 103

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Drug Profile

MB 103

Alternative Names: HER2(EQ)BBζ/CD19t+ Tcm; HER2-BBζ CAR-T cells; HER2-specific chimeric antigen receptor T cells; HER2-targeted CAR T cell therapy; MB 103 HER2-specific CAR T cells; MB-103; MB-103 HER2 CAR

Latest Information Update: 12 Apr 2024

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At a glance

  • Originator City of Hope National Medical Center
  • Developer City of Hope National Medical Center; Mustang Bio
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Brain metastases; Glioblastoma

Most Recent Events

  • 28 Mar 2024 Discontinued - Phase-I for Brain metastases in USA (Intraventricular)
  • 28 Mar 2024 Discontinued - Phase-I for Glioblastoma (Late-stage disease, Recurrent, Second-line therapy or greater) in USA (Intratumoural)
  • 05 Apr 2022 Phase I development for Brain metastases is ongoing in USA (Intraventricular)

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