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HPN 424

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Drug Profile

HPN 424

Alternative Names: HPN-424; PSMA/CD3-specific TriTAC

Latest Information Update: 15 Mar 2024

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At a glance

  • Originator Harpoon Therapeutics
  • Class Antineoplastics; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Prostate cancer

Most Recent Events

  • 11 Mar 2024 Harpoon Therapeutics has been acquired by Merck & Co
  • 27 Feb 2023 Harpoon Therapeutics terminates phase I/II trials in Prostate cancer (Late-stage disease, Hormone refractory, Metastatic disease, Second line therapy or greater) in United Kingdom, USA due to the decision not to proceed with the expansion phase of the study (IV) (NCT03577028)
  • 08 Apr 2022 Pharmacodynamics data from preclinical studies in Prostate cancer presented at the 113th Annual Meeting of the American Association for Cancer Research (AACR-2022)

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