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Quemliclustat - Arcus Biosciences

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Drug Profile

Quemliclustat - Arcus Biosciences

Alternative Names: AB-680; HY-125286; Small molecule CD73 inhibitor - Arcus Biosciences

Latest Information Update: 17 Dec 2025

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; Gilead Sciences; UCLAs Jonsson Comprehensive Cancer Center
  • Class 2 ring heterocyclic compounds; Amines; Antineoplastics; Fluorobenzenes; Phosphonic acids; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action 5-nucleotidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Adenocarcinoma
  • Phase II Cholangiocarcinoma; Non-small cell lung cancer
  • Phase I/II Colorectal cancer
  • Preclinical Malignant-mesothelioma
  • No development reported Cancer
  • Discontinued Prostate cancer

Most Recent Events

  • 12 Dec 2025 Arcus Biosciences completes enrolment in its phase III PRISM-1 trial for Pancreatic cancer (First line therapy) in the US, Spain, South Korea, Japan, Italy, France, Austria, Australia earlier this year (NCT06608927)
  • 10 Jul 2025 Quemliclustat - Arcus Biosciences receives Orphan Drug status for Pancreatic cancer in USA
  • 25 Apr 2025 Preclinical trials in Malignant mesothelioma in USA (Intraperitoneal) prior to April 2025

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