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DSG3 CAART

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Drug Profile

DSG3 CAART

Alternative Names: Desmoglein 3 chimeric autoantibody receptor T cells; DSG3-CAART

Latest Information Update: 01 Nov 2023

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At a glance

  • Originator University of Pennsylvania
  • Developer Cabaletta Bio
  • Class Gene therapies; Skin disorder therapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pemphigus vulgaris
  • New Molecular Entity No

Highest Development Phases

  • Phase I Pemphigus vulgaris

Most Recent Events

  • 01 Nov 2023 Phase-I development in Pemphigus-vulgaris (Treatment-experienced) is ongoing in USA (IV, Infusion) (NCT04422912)
  • 28 Oct 2023 No recent reports of development identified for phase-I development in Pemphigus-vulgaris(Treatment-experienced) in USA (IV, Infusion)
  • 13 Sep 2022 Interim efficacy, adverse event pharmacokinetic and IG data from a phase I DesCAARTes™ trial released by Cabaletta Bio

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