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Tegoprubart - Eledon Pharmaceuticals

Drug Profile

Tegoprubart - Eledon Pharmaceuticals

Alternative Names: Anti-CD40 ligand monoclonal antibody - ALS Therapy Development Institute/Eledon Pharmaceuticals; Anti-CD40 ligand monoclonal antibody - Eledon Pharmaceuticals; Anti-CD40L - ALS Therapy Development Institute; AT-1501

Latest Information Update: 14 May 2024

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At a glance

  • Originator ALS Therapy Development Institute
  • Developer Eledon Pharmaceuticals
  • Class Monoclonal antibodies
  • Mechanism of Action CD40 ligand inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Allotransplant rejection; Amyotrophic lateral sclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Amyotrophic lateral sclerosis; Renal transplant rejection
  • Phase I/II Pancreas transplant rejection
  • Phase I Xenotransplant rejection
  • Preclinical Liver transplant rejection
  • No development reported Autoimmune disorders
  • Discontinued Allotransplant rejection; IgA nephropathy

Most Recent Events

  • 07 May 2024 Adverse events and efficacy data from a phase Ib Renal transplant rejection released by Eledon Pharmaceuticals
  • 04 Apr 2024 Discontinued - Phase-II for IgA nephropathy (In the elderly, In adults) in Philippines, Poland, Sri Lanka, United Kingdom, Croatia, Thailand (IV)
  • 21 Mar 2024 Efficacy data from a phase Ib/II trial in Renal transplant rejection released by Eledon Pharmaceuticals
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