S 65487
Alternative Names: S 65487/VOB 560; S-65487; VOB-560Latest Information Update: 10 Sep 2024
At a glance
- Originator Servier; Vernalis
- Developer ADIR; Institut de Recherches Internationales Serviers; Novartis; Servier
- Class Antineoplastics
- Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase I/II Acute myeloid leukaemia
- Phase I Chronic lymphocytic leukaemia; Multiple myeloma; Non-Hodgkin's lymphoma
Most Recent Events
- 23 Jul 2024 Novartis terminates a phase-Ib trial in Acute myeloid leukaemia, Multiple myeloma and Non-Hodgkin's lymphoma (Combination therapy, Second-line therapy or greater) in Belgium, Spain, South Korea, Japan, Italy, Israel, Hong Kong, Finland and USA due to business reason (IV), (NCT04702425)
- 13 Jun 2024 Interim efficacy and adverse events data from a phase I/II trial in Acute myeloid leukemia presented at the 29th Congress of the European Haematology Association (EHA-2024)
- 11 Apr 2024 53466 S 65487 is still in I/II trials for Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma, Multiple Myeloma in France, United Kingdom, Spain, Australia (NCT03755154)