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Onfasprodil - Novartis

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Drug Profile

Onfasprodil - Novartis

Alternative Names: CAD-9271; MIJ 821

Latest Information Update: 16 Feb 2024

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At a glance

  • Originator Cadent Therapeutics
  • Developer Novartis; Novartis Pharmaceuticals
  • Class Antidepressants; Cyclopentanes; Fluorobenzenes; Pyridines
  • Mechanism of Action NR2B N Methyl D Aspartate receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Depressive disorders
  • Discontinued Major depressive disorder

Most Recent Events

  • 31 Dec 2023 Discontinued - Phase-I for Major depressive disorder (In volunteers, In adults) in United Kingdom (IV)
  • 31 Dec 2023 Discontinued - Phase-II for Major depressive disorder (Adjunctive treatment, In adults) in USA, Argentina, Brazil, Canada, Germany, Japan, Malaysia, Malaysia, Mexico, Netherlands, Poland, Russia, Turkey, Turkey, Taiwan, Spain, Slovakia (IV)
  • 28 Nov 2023 Novartis completes a phase II trial in Depressive disorder (Recurrent, Treatment-resistant) in the US, Spain, Japan and Poland (NCT05454410) (EudraCT-2021-005992-38)

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