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TMP 301

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Drug Profile

TMP 301

Alternative Names: Heptares 25; HTL-0014242; HTL14242; TMP-301

Latest Information Update: 06 Dec 2024

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At a glance

  • Originator Sosei Heptares
  • Developer Nxera Pharma; Tempero Bio
  • Class Antipsychotics; Anxiolytics; Behavioural disorder therapies; Benzonitrile; Drug withdrawal therapies; Neuroprotectants; Nitriles; Pyrimidines; Small molecules
  • Mechanism of Action Metabotropic glutamate receptor 5 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alcoholism
  • Phase I Cocaine-related disorders; Substance-related disorders
  • Discontinued Anxiety disorders; Neurological disorders; Psychiatric disorders

Most Recent Events

  • 14 Nov 2024 Phase-II clinical trials in Alcoholism in USA (PO) (NCT06648655)
  • 18 Oct 2024 Tempero Bio plans a phase-II trial for Alcoholism in December 2024 (PO), (NCT06648655),
  • 18 Oct 2024 Tempero Bio plans to initiate a phase I trial for Cocaine-related disorders (PO) (NCT06648668)

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