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APVO 436

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Drug Profile

APVO 436

Alternative Names: APVO-436

Latest Information Update: 15 Oct 2024

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At a glance

  • Originator Aptevo Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 01 Oct 2024 Aptevo Therapeutics plans a phase Ib trial for Acute myeloid leukemia (First line therapy, Combination therapy) (IV, Infusion) in October 2024 (NCT06634394)
  • 04 Apr 2024 Aptevo Therapeutics plans a dose optimization phase I/II trial for Acute myeloid leukaemia (First-line therapy, Combination therapy) in the first half of 2024 (IV)
  • 03 Apr 2024 APVO 436 is still in phase I trials for Acute myeloid leukaemia (Second-line therapy or greater) in USA (IV)

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