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Bexotegrast - Pliant Therapeutics

Drug Profile

Bexotegrast - Pliant Therapeutics

Alternative Names: PLN-74809

Latest Information Update: 09 Feb 2024

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At a glance

  • Originator Pliant Therapeutics
  • Class Anti-inflammatories; Antifibrotics; Butyric acids; Naphthyridines; Quinazolines; Small molecules
  • Mechanism of Action Integrin alphavbeta1 inhibitors; Integrin alphaVbeta6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis; Primary sclerosing cholangitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Idiopathic pulmonary fibrosis
  • Phase II Primary sclerosing cholangitis
  • Preclinical Primary biliary cirrhosis
  • Discontinued SARS-CoV-2 acute respiratory disease

Most Recent Events

  • 04 Feb 2024 Pliant Therapeutics announces intention to discuss the registration path with regulatory authorities
  • 04 Feb 2024 Adverse events data from a phase IIa trial in Primary sclerosing cholangitis released by Pliant Therapeutics
  • 08 Jan 2024 Pliant Therapeutics completes a phase IIa INTEGRIS-IPF trial for Idiopathic pulmonary fibrosis (Treatment-experienced) in USA (NCT05621252)
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