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Elraglusib - Actuate Therapeutics

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Drug Profile

Elraglusib - Actuate Therapeutics

Alternative Names: 9 ING 41

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator Northwestern University; University of Illinois at Chicago
  • Developer Actuate Therapeutics; Incyte Corporation
  • Class Antineoplastics; Benzofurans; Dioxolanes; Indoles; Pyrroles; Small molecules
  • Mechanism of Action Glycogen synthase kinase 3 alpha inhibitors; Glycogen synthase kinase 3 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Pancreatic cancer; Soft tissue sarcoma; Neuroblastoma; Adenocarcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adenoid cystic carcinoma; Myelofibrosis; Neuroblastoma; Pancreatic cancer; Salivary gland cancer
  • Phase I/II Cancer
  • Preclinical Brain cancer
  • No development reported Chronic lymphocytic leukaemia; Colorectal cancer

Most Recent Events

  • 21 Jan 2026 Actuate Therapeutics plans to initiate phase I portion of phase I/II trial for Cancer (Late-stage, Metastatic disease, Second-line therapy or greater) in second half of 2026 (PO, Tablet)
  • 06 Jan 2026 Efficacy and adverse event data from the phase I/II Actuate-1902 trial in Cancer released by Actuate Therapeutics
  • 15 Dec 2025 Efficacy and adverse events data from a phase II trial in Adenoid cystic carcinoma released by Actuate Therapeutics

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