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Lorigerlimab - MacroGenics

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Drug Profile

Lorigerlimab - MacroGenics

Alternative Names: AEX1344; EXPASY; MGD-019; PD-1 x CTLA-4 bispecific DART molecule

Latest Information Update: 25 Nov 2025

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At a glance

  • Originator MacroGenics
  • Class Antineoplastics; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Programmed cell death 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gynaecological cancer; Ovarian cancer; Prostate cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 25 Nov 2025 MacroGenics terminates a phase II LORIKEET trial for Prostate cancer (Combination therapy, Metastatic disease, Hormone refractory) in United Kingdom, Spain, Puerto Rico, Poland, Georgia, France, Bulgaria, Belgium, USA (IV) (NCT05848011)
  • 30 Oct 2025 M.D. Anderson Cancer Center plans a phase I/II trial for Rectal cancer (Recurrent, Second-line therapy or greater, Combination therapy) in USA (IV, Infusion) in April 2026 (NCT07223567 )
  • 28 Oct 2025 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)

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