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Lorigerlimab - MacroGenics

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Drug Profile

Lorigerlimab - MacroGenics

Alternative Names: AEX1344; EXPASY; MGD-019; PD-1 x CTLA-4 bispecific DART molecule

Latest Information Update: 02 Mar 2026

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At a glance

  • Originator MacroGenics
  • Class Antineoplastics; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Programmed cell death 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gynaecological cancer; Ovarian cancer; Prostate cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 23 Feb 2026 Adverse event data from the phase II LINNET trial in Gynaecological cancer released by MacroGenics
  • 23 Feb 2026 The US FDA places a partial clinical hold on its phase II LINNET trial for Gynaecological cancer (Late-stage disease, Second-line therapy or greater) in South Korea, Canada, USA (IV), due to the occurrence of safety events (NCT06730347)
  • 28 Jan 2026 MacroGenics terminates a phase II trial for Rectal cancer (Recurrent, Second-line therapy or greater, Combination therapy) due to no enrollment (NCT07223567)

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