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Benmelstobart - Apollomics/Chia Tai Tianqing Pharmaceutical Group

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Drug Profile

Benmelstobart - Apollomics/Chia Tai Tianqing Pharmaceutical Group

Alternative Names: Anti-PD-L1 monoclonal antibody - Apollomics/Chia Tai Tianqing Pharmaceutical Group; APL 502; CBT-502; PD-L1 antibody - Apollomics/Chia Tai Tianqing Pharmaceutical Group​; TQ-B2450

Latest Information Update: 04 Jul 2024

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At a glance

  • Originator Apollomics; Crown Bioscience
  • Developer Apollomics; Chia Tai Tianqing Pharmaceutical Group
  • Class Antineoplastics; Antivirals; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Small cell lung cancer
  • Preregistration Endometrial cancer
  • Phase III Biliary cancer; Non-small cell lung cancer; Ovarian cancer; Renal cancer; Squamous cell cancer
  • Phase II/III Adenocarcinoma; Gastric cancer
  • Phase II Diffuse large B cell lymphoma; Gynaecological cancer; Hepatitis B; Hodgkin's disease; Liver cancer; Nasopharyngeal cancer; Uterine cancer
  • Phase I/II Acral lentiginous melanoma; Cholangiocarcinoma
  • Phase I Solid tumours
  • No development reported Triple negative breast cancer

Most Recent Events

  • 04 Jul 2024 Chia Tai Tianqing Pharmaceutical Group plans a phase III trial in Small cell lung cancer (Combination therapy) in China (IV) in September 2024 (NCT06469879)
  • 31 May 2024 Efficacy and adverse events data from phase-II trial in Biliary cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 31 May 2024 Safety and efficacy data from a phase II trial in Squamous cell cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
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