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Acapatamab - Amgen

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Drug Profile

Acapatamab - Amgen

Alternative Names: AMG 160; anti-PSMAxanti-CD3-BiTE; anti-PSMAxanti-CD3-BiTE-bispecific-T-cell-engager

Latest Information Update: 14 Apr 2025

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At a glance

  • Originator Amgen
  • Developer Amgen; BeiGene
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Non-small cell lung cancer; Prostate cancer

Most Recent Events

  • 08 Apr 2025 Amgen terminates a phase I trial in Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease) in Austria, Belgium, Canada, France, Japan, the Netherlands, Singapore, the US and Taiwan, due to sponsor decision (NCT03792841)
  • 07 Nov 2023 Amgen terminates a phase I/II trial in Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease) in United Kingdom, Sweden, Spain, Australia, USA, Canada, Netherlands, Germany, Italy (IV) due to strategic reasons (NCT04631601)
  • 27 Feb 2023 Phase-I clinical trials in Non-small cell lung cancer in USA (IV)

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