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Adagrasib - Mirati Therapeutics

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Drug Profile

Adagrasib - Mirati Therapeutics

Alternative Names: KRAZATI; MRTX 849

Latest Information Update: 28 Jun 2025

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At a glance

  • Originator Array BioPharma; Mirati Therapeutics
  • Developer Bristol-Myers Squibb; Mirati Therapeutics; Novartis; University of Texas M. D. Anderson Cancer Center; Whitehawk Therapeutics; ZAI Lab
  • Class Acetonitriles; Antineoplastics; Halogenated hydrocarbons; Naphthalenes; Piperazines; Pyridones; Pyrimidines; Pyrrolidines; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Non-small cell lung cancer
  • Phase II Solid tumours
  • Phase I Pancreatic cancer
  • Preclinical Bladder cancer

Most Recent Events

  • 28 Jun 2025 No recent reports of development identified for phase-I development in Solid-tumours(Inoperable/Unresectable, Late-stage disease, Metastatic disease) in China (PO)
  • 25 Apr 2025 Efficacy and adverse events data from a phase I/II KRYSTAL-1 trial in Non-small cell lung cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 25 Apr 2025 Aadi Bioscience in collaboration with Mirati Therapeutics terminates a phase I/II trial in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in USA (IV) due to change in business objectives (NCT05840510)

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