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THN 391

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Drug Profile

THN 391

Alternative Names: Anti-fibrin monoclonal antibody - Therini Bio; THN-391

Latest Information Update: 04 Aug 2025

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At a glance

  • Originator Gladstone Institutes; MedaRed; University of California at San Francisco
  • Developer Gladstone Institutes; Therini Bio; University of California at San Francisco
  • Class Antidementias; Eye disorder therapies; Monoclonal antibodies; Neuroprotectants
  • Mechanism of Action Fibrin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Alzheimer's disease; Dementia; Diabetic macular oedema
  • Preclinical Multiple sclerosis

Most Recent Events

  • 08 May 2025 Phase-I clinical trials in Alzheimer's disease (In the elderly) in Netherlands (IV) (EudraCT2024-519899-72-00)
  • 29 Apr 2025 Adverse events data from a phase I trial in Dementia released by Therini Bio
  • 29 Apr 2025 Therini Bio plans phase Ib trials in Diabetic Macular Edema

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