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NCE 401

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Drug Profile

NCE 401

Alternative Names: NCE-401; TU-2218

Latest Information Update: 10 Oct 2024

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At a glance

  • Originator TiumBio
  • Class Antifibrotics; Antineoplastics; Small molecules
  • Mechanism of Action Transforming growth factor beta type I receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours; Squamous cell cancer
  • No development reported Cancer; Idiopathic pulmonary fibrosis

Most Recent Events

  • 04 Oct 2024 Phase-I/II clinical trials in Squamous cell cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in South Korea (PO) (NCT05204862)
  • 04 Oct 2024 Phase-I/II clinical trials in Squamous cell cancer (Late-stage disease, Second-line therapy or greater, Monotherapy) in South Korea (PO)
  • 01 Jun 2024 Efficacy and adverse events data from a phase Ib/IIa trial in Solid tumours released by TiumBio

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