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Methotrexate intravitreal - Aldeyra Therapeutics

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Drug Profile

Methotrexate intravitreal - Aldeyra Therapeutics

Alternative Names: ADX 2191

Latest Information Update: 17 Oct 2024

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At a glance

  • Originator Harvard Medical School; Massachusetts Eye and Ear
  • Developer Aldeyra Therapeutics
  • Class Abortifacients; Anti-inflammatories; Antiasthmatics; Antifibrotics; Antineoplastics; Antipsoriatics; Antirheumatics; Benzamides; Disease-modifying antirheumatics; Eye disorder therapies; Glutamates; Heart failure therapies; Pterins; Small molecules
  • Mechanism of Action Antimetabolites; Immunosuppressants; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinitis pigmentosa; Proliferative vitreoretinopathy; Intraocular lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Preregistration Intraocular lymphoma
  • Phase III Proliferative vitreoretinopathy
  • Phase II Retinitis pigmentosa

Most Recent Events

  • 01 Oct 2024 Aldeyra Therapeutics plans to initiate a phase II/III trial in Retinitis pigmentosa in 2H of 2024
  • 29 Jun 2023 Aldeyra Therapeutics plans to meet with regulatory authorities to discuss the initiation of a pivotal phase II/III trial in Retinitis pigmentosa
  • 29 Jun 2023 Efficacy and adverse events data from a phase II trial in Retinitis pigmentosa released by Aldeyra Therapeutics

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