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Zilovertamab vedotin - VelosBio

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Drug Profile

Zilovertamab vedotin - VelosBio

Alternative Names: MK 2140; VLS 101

Latest Information Update: 07 Jan 2025

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At a glance

  • Originator Merck Sharp & Dohme; VelosBio
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Cell cycle inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diffuse large B cell lymphoma
  • Phase II Bladder cancer; Breast cancer; Chronic lymphocytic leukaemia; Follicular lymphoma; Gastric cancer; Haematological malignancies; Mantle-cell lymphoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Richter's syndrome; Solid tumours
  • Preclinical Ewing's sarcoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 27 Dec 2024 Phase-III clinical trials in Diffuse large B cell lymphoma (First-line therapy, Combination therapy) in USA (IV) (NCT06717347)
  • 09 Dec 2024 Interim adverse events data from a phase II trial in Diffuse large B cell lymphoma released by Merck
  • 08 Dec 2024 Merck Sharp & Dohme plans a phase III waveLINE-010 trial in Diffuse large B cell lymphoma (Combination therapy, First-line therapy) in December 2024 (IV, Infusion) (NCT06717347)

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