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ZW 49

Drug Profile

ZW 49

Alternative Names: anti-HER2 x HER2 ADC - Zymeworks; ZW49

Latest Information Update: 15 Jan 2020

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At a glance

  • Originator Zymeworks
  • Class Antineoplastics; Bispecific antibodies; Drug conjugates; Immunoconjugates
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Breast cancer; Oesophageal cancer; Solid tumours
  • Preclinical Gastric cancer

Most Recent Events

  • 14 Jan 2020 Interim efficacy and safety data from phase II trial in HER-2 expressing Cancers released by Zymeworks
  • 24 Jan 2019 Phase-I clinical trials in Breast cancer (Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater, Late-stage disease) in USA (IV)
  • 24 Jan 2019 Phase-I clinical trials in Oesophageal cancer (Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater, Late-stage disease) in USA (IV)
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