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BMS 986416

Drug Profile

BMS 986416

Alternative Names: AVID-200; AVID200 DP; BMS-986416; TGFβ inhibitor - Bristol Myers Squibb

Latest Information Update: 28 Apr 2025

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At a glance

  • Originator Formation Biologics
  • Developer Bristol-Myers Squibb
  • Class Antifibrotics; Antineoplastics; Immunoglobulin fusion proteins; Immunotherapies; Skin disorder therapies
  • Mechanism of Action Transforming growth factor beta1 inhibitors; Transforming growth factor beta3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • No development reported Diffuse scleroderma; Myelofibrosis

Most Recent Events

  • 09 Apr 2025 Development for phase I trial in Solid-tumours(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan, USA and Canada is still ongoing (Parenteral) (NCT04943900)
  • 09 Apr 2025 Development for phase I trial in Solid-tumours(Monotherapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan, USA and Canada is still ongoing (Parenteral) (NCT04943900)
  • 27 Feb 2025 Bristol-Myers Squibb completes the phase I trial in Solid tumours (Combination therapy, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater, Late-stage disease) in Argentina, Belgium, Canada, Chile, Japan, Netherlands and USA (Parenteral) (NCT04943900)

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