BMS 986416
Alternative Names: AVID-200; AVID200 DP; BMS-986416; TGFβ inhibitor - Bristol Myers SquibbLatest Information Update: 28 Apr 2025
At a glance
- Originator Formation Biologics
- Developer Bristol-Myers Squibb
- Class Antifibrotics; Antineoplastics; Immunoglobulin fusion proteins; Immunotherapies; Skin disorder therapies
- Mechanism of Action Transforming growth factor beta1 inhibitors; Transforming growth factor beta3 inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase I Solid tumours
- No development reported Diffuse scleroderma; Myelofibrosis
Most Recent Events
- 09 Apr 2025 Development for phase I trial in Solid-tumours(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan, USA and Canada is still ongoing (Parenteral) (NCT04943900)
- 09 Apr 2025 Development for phase I trial in Solid-tumours(Monotherapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan, USA and Canada is still ongoing (Parenteral) (NCT04943900)
- 27 Feb 2025 Bristol-Myers Squibb completes the phase I trial in Solid tumours (Combination therapy, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater, Late-stage disease) in Argentina, Belgium, Canada, Chile, Japan, Netherlands and USA (Parenteral) (NCT04943900)