IFx 2.0
Alternative Names: Autologous whole-cell ImmuneFx™ cancer vaccine therapy; Emm55 Streptococcal antigen pDNA; IFx-Hu2.0; pDNA Intralesional cancer vaccineLatest Information Update: 30 Jun 2025
At a glance
- Originator Morphogenesis
- Developer H. Lee Moffitt Cancer Center and Research Institute; TuHURA Biosciences
- Class Antineoplastics; Cancer vaccines; Synthetic vaccines
- Mechanism of Action Immunostimulants
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Phase III Merkel cell carcinoma
- Phase I Basal cell cancer; Malignant melanoma; Squamous cell cancer
Most Recent Events
- 24 Jun 2025 Phase-III clinical trials in Merkel cell carcinoma (Metastatic disease, First-line therapy, Adjunctive treatment, Late-stage disease) in USA (Intralesional) (NCT06947928)
- 09 Jun 2025 TuHURA Biosciences plans a phase-III registration trial for Merkel Cell Carcinoma (First-line therapy, Adjunctive treatment, Metastatic disease, Late-stage disease) in USA (Intralesional, Injection) in June 2025 (TuHURA Bio Pipeline, March 2025) (NCT06947928)
- 30 Apr 2025 Phase-I clinical trials in Merkel cell carcinoma (Adjunctive treatment, Recurrent, Inoperable/Unresectable, Late-stage disease, Metastatic disease, First-line therapy) (Intralesional) (NCT06940440)