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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 24 Apr 2026

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis; Merck KGaA
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; TYRO3 receptor protein tyrosine kinase antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Colorectal cancer
  • Phase III Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours; Squamous cell cancer
  • Phase II Bone cancer; Liver cancer; Prostate cancer; Soft tissue sarcoma; Thyroid cancer
  • Phase I/II Germ cell cancer
  • Phase I Leiomyosarcoma; Liposarcoma; Solid tumours; Uterine cancer

Most Recent Events

  • 17 Apr 2026 Phase-II clinical trials in Soft tissue sarcoma (Late-stage disease, Metastatic disease, Combination therapy) in USA (PO) (NCT07283731)
  • 16 Apr 2026 M.D. Anderson Cancer Center plans a phase II ZEPHYR trial for Anaplastic thyroid carcinoma (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Combination therapy) in USA) (IV) in September 2026 (NCT07470489)
  • 14 Apr 2026 M.D. Anderson Cancer Center plans a phase II trial for Neuroblastoma (Recurrent, Metastatic disease, Inoperable/unresectable) in USA (PO) in October 2026 (NCT07527169)

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