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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 24 Oct 2025

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; TYRO3 receptor protein tyrosine kinase antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer; Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours; Squamous cell cancer
  • Phase II Liver cancer; Prostate cancer; Thyroid cancer
  • Phase I Solid tumours; Uterine cancer

Most Recent Events

  • 21 Oct 2025 Hoosier Cancer Research Network in collaboration with Exelixis andMedical College of Wisconsin plans a phase II NAPOLEON trial for Prostate cancer (Metastatic disease, Second-line therapy or greater ) in USA (PO) in May 2026 (NCT07218666)
  • 20 Oct 2025 Efficacy and adverse events data from a phase III STELLAR-303 trial in Colorectal cancer released by Exelixis
  • 07 Oct 2025 Phase-I clinical trials in Uterine cancer (Combination therapy, Second-line therapy or greater, Recurrent) in USA (PO) (NCT06795009)

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