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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis; Merck KGaA
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; TYRO3 receptor protein tyrosine kinase antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Colorectal cancer
  • Phase III Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours; Squamous cell cancer
  • Phase II Liver cancer; Prostate cancer; Thyroid cancer
  • Phase I/II Germ cell cancer
  • Phase I Leiomyosarcoma; Liposarcoma; Soft tissue sarcoma; Solid tumours; Uterine cancer

Most Recent Events

  • 11 Jan 2026 Preregistration for Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 11 Jan 2026 Exelixis plans a confirmatory phase III trial for Colorectal cancer
  • 11 Jan 2026 Exelixis plans a STELLAR-201 trial for Colorectal cancer in mid-2026 (PO)

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