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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; TYRO3 receptor protein tyrosine kinase antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer; Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours; Squamous cell cancer
  • Phase II Liver cancer; Prostate cancer
  • Phase I Solid tumours

Most Recent Events

  • 31 Jul 2025 Phase-II/III clinical trials in Neuroendocrine tumours (Metastatic disease, Late-stage disease, Inoperable/Unresectable, Second-line therapy or greater) in USA, Puerto Rico (PO) (NCT06943755)
  • 28 Jul 2025 Exelixis plans regulatory filling for Colorectal cancer
  • 02 Jul 2025 University of California plans a phase II ZAMBONI trial for Renal cell carcinoma (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) in September 2025 (NCT07043608)

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