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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 15 Sep 2026

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis; Merck KGaA
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; TYRO3 receptor protein tyrosine kinase antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Colorectal cancer
  • Phase III Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours; Squamous cell cancer
  • Phase II Bone cancer; Liver cancer; Meningioma; Prostate cancer; Soft tissue sarcoma; Thyroid cancer
  • Phase I/II Germ cell cancer
  • Phase I Leiomyosarcoma; Liposarcoma; Uterine cancer
  • No development reported Solid tumours

Most Recent Events

  • 01 Sep 2026 Washington University School of Medicine suspends a phase-I trial in Soft tissue sarcoma (Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater, Combination therapy) in USA, due to a protocol amendment (PO) (NCT06968988)
  • 28 Aug 2026 No recent reports of development identified for phase-I development in Solid-tumours(Inoperable/Unresectable, Late-stage disease, Metastatic disease, Monotherapy) in USA (PO)
  • 19 Aug 2026 Exelixis plans a phase I trial in Solid tumors (Second-line therapy or greater, In children, In infants, In adolescents) in September 2026 (PO) (NCT07773454)

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