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Zanzalintinib - Exelixis

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Drug Profile

Zanzalintinib - Exelixis

Alternative Names: XL-092

Latest Information Update: 02 Jul 2025

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis
  • Class Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Proto-oncogene protein c-mer inhibitors; Proto-oncogene protein c-met inhibitors; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer; Renal cell carcinoma
  • Phase II/III Squamous cell cancer
  • Phase II Liver cancer
  • Phase I Solid tumours

Most Recent Events

  • 29 Jun 2025 Exelixis plans a phase II trial for Renal cell carcinoma (Metastatic disease, Second-line therapy or greater, Inoperable/unresectable, late-stage disease, Second-line therapy or greater) in USA (PO) (NCT07043608)
  • 22 Jun 2025 Efficacy and adverse events data from a phase III STELLAR-303 trial for Colorectal cancer released by Exelixis
  • 10 Jun 2025 Exelixis terminates phase I/II STELLAR-009 clinical trials in Solid tumours (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO) prior to starting the phase II portion due to a business decision (NCT06191796)

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